Werner Näf (1894-1959)

Werner Syndrome

Werner Syndrome (WS) is an autosomal recessive disease that leads to the premature manifestation of clinical symptoms associated with normal aging. Clinical symptoms include: short stature, graying/loss of hair, osteoporosis, cataracts, atherosclerosis, type II diabetes, hypogonadism, skin ulcers, reduced fertility, and high incidence of malignant neoplasms. They appear in one’s 20’s and 30’s, ...

Werner Syndrome

Werner syndrome is a premature aging disease caused by the mutation in the WRN gene. The cloning and characterization of the WRN gene and its product allows investigators to study the disease and the human aging process at molecular level. This review summarizes the recent progresses on various aspects of the WRN research including functional analysis of the protein, interactive cloning, comple...

Edward Joseph Conway, 1894-1968

Ernest Basil Verney, 1894-1967.

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Sir James Paget (1814-1894).

Sir James Paget (Fig. 1) formed with William Fergusson (1808–1862) and Sir Benjamin Brodie (1783–1762) a triumvirate of surgical ‘greats’ in England in the nineteenth century w1x. Paget was born in Great Yarmouth, Norfolk, England, and until 20 yr of age had not ventured further than a few miles from his birthplace. His father, Samuel, was a prosperous businessman who unfortunately went bankrup...